Studies of multicomponent Kinugasa reactions in aqueous media |
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| Authors: | Craig S McKay David C Kennedy |
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| Institution: | a Steacie Institute for Molecular Sciences, National Research Council, 100 Sussex Drive, Ottawa, Canada K1A 0R6
b Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Canada K1N 6N5 |
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| Abstract: | Micelle-promoted, copper-catalyzed multicomponent Kinugasa reactions were studied in aqueous media. Reactions were performed in a ‘single pot’ for a series of in situ generated C,N-diphenylnitrones with Cu(I) phenylacetylide providing β-lactams in yields of 45-85%. Substituents affect the reaction by either accelerating cycloaddition or minimizing side reactions. |
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