Csp-tellurium copper cross-coupling: synthesis of alkynyl tellurides a novel class of antidepressive-like compounds |
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Authors: | Afamefuna Elvis Okoronkwo Ricardo Frederico Schumacher Cristiane Luchese Cristina Wayne Nogueira |
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Affiliation: | a Laboratório de Síntese, Reatividade, Avaliação Farmacológica e Toxicológica de Organocalcogênios, Departamento de Química, CCNE, UFSM, Santa Maria, RS, Brazil b Department of Chemistry, Federal University of Technology, P.M.B. 704 Akure, Ondo State, Nigeria |
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Abstract: | We present here the results on the synthesis of functionalized alkynyl tellurides using the reaction of vinyl, alkynyl, and aryl tellurides with several alkynyl iodides catalyzed by copper iodide. The reaction proceeded cleanly under mild reaction conditions, at room temperature, in the absence of base and ligand giving alkynyl tellurides in acceptable yields. The obtained compounds 3a-c and 3m-o were screened for antidepressive-like activity using the tail suspension test (TST) in mice. Compounds 3a-c and 3m-o administered at 10 mg/kg by oral route produced a significant antidepressant-like effect on the TST in mice. |
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Keywords: | Copper cross-coupling Tellurides Pharmacological activity |
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