An improved process for the synthesis of DMTMM-based coupling reagents |
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| Authors: | Steven A. Raw |
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| Affiliation: | AstraZeneca, Process Research and Development, Silk Court Business Park, Charter Way, Macclesfield, Cheshire, SK11 8AA, UK |
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| Abstract: | A simple, robust and high-yielding process for the preparation of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium tetrafluoroborate (DMTMM BF4) and hexafluorophosphate (DMTMM PF6) has been developed, which avoids the use of expensive or unusual reagents. |
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