Synthetic studies on amphidinolides C and F: synthesis of the C18-C29 segment of amphidinolide F |
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| Authors: | Alan Armstrong Constantina Pyrkotis |
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| Institution: | Department of Chemistry, Imperial College London, South Kensington, London SW7 2AZ, UK |
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| Abstract: | The C18-C29 segment of amphidinolide F is synthesised in 12 steps from 1,4-butanediol. Key steps include a mono-Sharpless dihydroxylation of a dienoate, iodocyclisation to construct the trans-THF ring and an E-selective Wittig reaction to introduce the C25-C26 olefin. |
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| Keywords: | Natural products Dihydroxylations Iodine Cyclisations Wittig reactions |
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