Palladium-catalyzed carbonylative cyclization of 2-bromobenzaldehyde with primary amines leading to isoindolin-1-ones |
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| Authors: | Chan Sik Cho Wen Xiu Ren |
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| Affiliation: | Department of Applied Chemistry, Kyungpook National University, Daegu 702-701, South Korea |
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| Abstract: | 2-Bromobenzaldehyde is carbonylatively cyclized with primary amines under carbon monoxide pressure in DMF at 100 °C in the presence of a catalytic amount of a palladium catalyst to give the corresponding isoindolin-1-ones in moderate to high yields. |
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| Keywords: | 2-Bromobenzaldehyde Carbonylative cyclization Isoindolin-1-ones Palladium catalyst Primary amines |
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