Total synthesis of (+)-spiculoic acid A |
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Authors: | Daisuke Matsumura |
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Affiliation: | Department of Applied Chemistry, Keio University, Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan |
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Abstract: | The total synthesis of natural (+)-spiculoic acid A, a new cytotoxic marine natural product of polyketide origin, has been accomplished for the first time. The key step of the total synthesis was a stereoselective and high-yielding intramolecular Diels-Alder reaction of a highly functionalized (E,E,E)-2,7,9-dodecanal derivative for the construction of the core tetrahydroindan-2-one skeleton. |
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Keywords: | (+)-Spiculoic acid A Total synthesis Marine natural product Cytotoxicity Intramolecular Diels-Alder reaction Suzuki-Miyaura coupling |
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