An efficient regioselective synthesis of functionalized biphenyls via sequential reactions of aromatic aldehydes and β-keto esters or ketones |
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| Authors: | Anindra Sharma |
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| Affiliation: | Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226 001, India |
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| Abstract: | Knoevenagel/Michael/Aldol reactions of aromatic aldehydes and β-keto esters/ketones in a sequential manner yielded intermediate cyclohexanones in good yields. The latter, on oxidative aromatization with iodine, afforded functionalized biphenyls with at least one phenolic hydroxyl in moderate to good yields. |
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| Keywords: | Polysubstituted benzenes Aldol reactions Michael additions Knoevenagel reaction Regioselective Hydroxylated biphenyls |
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