An efficient regioselective synthesis of functionalized biphenyls via sequential reactions of aromatic aldehydes and β-keto esters or ketones |
| |
| Authors: | Anindra Sharma |
| |
| Institution: | Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226 001, India |
| |
| Abstract: | Knoevenagel/Michael/Aldol reactions of aromatic aldehydes and β-keto esters/ketones in a sequential manner yielded intermediate cyclohexanones in good yields. The latter, on oxidative aromatization with iodine, afforded functionalized biphenyls with at least one phenolic hydroxyl in moderate to good yields. |
| |
| Keywords: | Polysubstituted benzenes Aldol reactions Michael additions Knoevenagel reaction Regioselective Hydroxylated biphenyls |
| 本文献已被 ScienceDirect 等数据库收录！ |
