Three-component Ugi-Smiles couplings of cyclic imines |
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| Authors: | Laurent El Kaïm Laurence Grimaud Julie Oble Simon Wagschal |
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| Institution: | Laboratoire Chimie et Procédés, DCSO, UMR 7652, Ecole Nationale Supérieure de Techniques Avancées, 32 Bd Victor, Paris 75015, France |
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| Abstract: | Cyclic imines react with isocyanides and electron-deficient phenols to afford N-aryl piperidines and pyrrolidines in good yields (Ugi-Smiles couplings of cyclic imines). The starting imines were formed by oxidation with N-chlorosuccinimide followed by a base-induced dehydrochlorination. |
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