An approach to the synthesis of dimeric resveratrol natural products via a palladium-catalyzed domino reaction |
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| Authors: | Jenna L. Jeffrey |
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| Affiliation: | Department of Chemistry, University of California, Berkeley, CA 94720, USA |
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| Abstract: | A route for the rapid assembly of the carbon framework of several resveratrol natural products is presented. A palladium-catalyzed domino reaction of bromostilbene derivative 6 and tolane 7, involving two sequential Heck coupling reactions, provides access to the benzofulvene-based core of various resveratrol-derived natural products. The carbon skeleton of pallidol and its congeners is achieved by a Lewis acid-induced Nazarov-type oxidative cyclization of 9. |
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