Synthesis of γ-halogenated ketones via the Ce(IV)-mediated oxidative coupling of cyclobutanols and inorganic halides |
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| Authors: | Brian M. Casey |
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| Affiliation: | Department of Chemistry, Lehigh University, Bethlehem, PA 18015, USA |
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| Abstract: | A straightforward method for the synthesis of γ-halo-substituted ketones formed via the CAN-initiated oxidative addition of halides to 1-substituted cyclobutanols has been developed. This method has short reaction times, and provides access to a range of bromo and iodo γ-substituted ketones in good to excellent yields. |
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| Keywords: | CAN Cyclobutanol γ-Substituted ketone Oxidative coupling |
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