Acyclic and cyclic thioenamino peptides: solution- and solid-phase synthesis |
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Authors: | Lee Goren |
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Affiliation: | School of Chemistry, Tel-Aviv University, Ramat Aviv 69978, Israel |
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Abstract: | Seven- and 10-membered cyclic thioenamino peptides, that is, 1,4-thiazepinone (11) and cyclic thioenamino peptide 9 (which represents a potential γ-turn mimetic), were synthesized, and the structure of 11 was secured by X-ray diffraction analysis of its TFA salt. The aforementioned compounds were prepared in solution and by solid-phase synthesis. Additionally, we have prepared thioenamino diketopiperazine synthon 16. |
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Keywords: | Cyclic peptides Solid-phase synthesis FGly Endiamine Thioenamine |
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