Divergent synthesis of isoindolo[2,1-a]indole and indolo[1,2-a]indole through copper-catalysed C- and N-arylations |
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| Authors: | Nekane Barbero,Esther Domí nguez |
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| Affiliation: | Kimika Organikoa II Saila, Zientzia eta Teknologia Facultatea, Euskal Herriko Unibertsitatea, PO Box 644, 48080 Bilbao, Spain |
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| Abstract: | A simple and efficient synthetic route to both isoindolo[2,1-a]indole and its structural isomer indolo[1,2-a]indole skeletons is presented. The key steps of the strategy are based on copper-catalysed Caryl-C and Caryl-N bond formation reactions, respectively. Moreover, we report the first copper-mediated intramolecular C-H functionalisation of an indole. |
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| Keywords: | Indoles Copper catalysts Arylation |
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