High specific activity tritium labelling of some sigma-1 receptor agonists |
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Authors: | David G. Ahern Richard J. Seguin Crist N. Filer |
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Affiliation: | (1) PerkinElmer Health Sciences, Inc., 940 Winter St., Waltham, MA 02451, USA; |
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Abstract: | The high specific activity tritiation of (+)-SKF-10,047 (1) and N,N-dimethyltryptamine (4) is described. [N-allyl-3H] (+)-SKF-10,047 (3) was prepared by Lindlar catalyst tritiation of (+)-N-propargylnormetazocine (2) and [N-methyl-3H] N,N-dimethyltryptamine (6) was synthesized by the alkylation of N-methyltryptamine (5) with [3H] methyl iodide. Both sigma-1 synthetic agonist 3 and endogenous agonist 6 have been useful in studying this receptor. |
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