An expeditious protocol for sesquiterpene-cored functionalized arenes from S-(−)-citronellal |
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Authors: | Atul Goel Deepti Verma |
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Institution: | Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226 001, India |
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Abstract: | An expeditious straightforward synthesis of sesquiterpene-cored arenes functionalized with electron-withdrawing or electron-donating substituents is described and illustrated by Michael addition of S-(−)-citronellal on functionalized 2H-pyran-2-one in a single step at room temperature. The reaction was further generalized by synthesizing isoprenylated 9,10-dihydrophenanthrene-2-carbonitrile using 5,6-dihydro-2-oxo-4-sec-amino-2H-benzoh]chromene-3-carbonitriles and S-(−)-citronellal under similar reaction conditions. |
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Keywords: | Bisabolene Sesquiterpene 2H-Pyran-2-ones Citronellal Ring transformation approach |
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