Total synthesis of cucurbitoside A using a novel fluorous protecting group |
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Authors: | Masaru Kojima |
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Institution: | Niigata University of Pharmacy and Applied Life Sciences, 265-1 Higashijima, Akiha-ku, Niigata 956-8603, Japan |
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Abstract: | The first total synthesis of cucurbitoside A was achieved using a new fluorous N-phenylcarbamoyl (FCar) protecting group. The FCar group was introduced into carbohydrates in high yield and was selectively removed with Bu4NNO2 without damaging other acyl protecting groups. The synthetic intermediates were easily isolated by fluorous solid-phase extraction. |
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Keywords: | Fluorous Fluorous solid-phase extraction Cucurbitoside N-Phenylcarbamoyl group |
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