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Total synthesis of (+)-epiquinamide from d-mannitol
Authors:Subhash Ghosh  J. Shashidhar
Affiliation:Indian Institute of Chemical Technology, Hyderabad 500 007, India
Abstract:The total synthesis of (+)-epiquinamide, a novel quinolizidine alkaloid isolated from the Ecuadoran poison frog, Epipedobates tricolor is described. The key step includes a ring-closing metathesis reaction to construct both the six member rings. d-Mannitol was used as a chiral pool material.
Keywords:Epiquinamide   Ring-closing metathesis     smallcaps"  >d-Mannitol
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