Facile reaction of thiols and amines with alkyl 4-hydroxy-2-alkynoates in water under neutral conditions and ultrasound irradiation |
| |
| Authors: | Antonio Arcadi Maria Alfonsi Fabio Marinelli |
| |
| Affiliation: | Department of Chemistry, Chemical Engineering and Materials-University of L’Aquila-Via Vetoio, 67010 L’Aquila, Italy |
| |
| Abstract: | This Letter describes an alternative protocol for the Michael addition of thiols to 4-hydroxy-2-alkynoates. The reaction proceeds at room temperature in water under ultrasound irradiation. With amines instead of thiols a sequential conjugate addition/lactonization reaction leads to important 4-amino-furan-2-one derivatives. |
| |
| Keywords: | Aqueous medium Ultrasound irradiation Hetero-Michael reaction Thiols Amines 4-Hydroxy-2-alkynoates |
| 本文献已被 ScienceDirect 等数据库收录！ |
