Tandem aza-Claisen rearrangement and ring-closing metathesis reactions: the stereoselective synthesis of functionalised carbocyclic amides |
| |
| Authors: | Michael D Swift |
| |
| Institution: | WestChem, Department of Chemistry, The Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK |
| |
| Abstract: | A one-pot, tandem process has been developed for the efficient synthesis of functionalised carbocyclic amides. A substituted cyclopentenyl trichloroacetamide was synthesised using a tandem thermal aza-Claisen rearrangement and RCM process, while an analogous cyclohexenyl trichloroacetamide was generated with high diastereoselectivity using a tandem MOM-ether directed metal-catalysed aza-Claisen rearrangement and RCM process. |
| |
| Keywords: | Tandem reactions Ring-closing metathesis Aza-Claisen rearrangements Carbocyclic amides |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
