Catalytic monoalkylation of 1,2-diols |
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| Authors: | Toshihide Maki |
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| Institution: | Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan |
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| Abstract: | A catalytic monoalkylation of 1,2-diols by using a weak base has been developed. Copper(II) dichloride and boronic acids are effective catalysts for activating 1,2-diols in the presence of potassium carbonate as a base. Various 1,2-diols were selectively monoalkylated with allyl-, benzyl- and alkyl- halides in DMF by choosing a suitable catalyst for each 1,2-diols. |
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| Keywords: | Diol Alkylation Lewis acid Allylation Benzylation |
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