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An improved amide coupling procedure for the synthesis of N-(pyridin-2-yl)amides |
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| Authors: | Allyn T Londregan Gregory Storer Ceshea Wooten Xiaojing Yang Joseph Warmus |
| Institution: | Pfizer Global Research and Development, Groton, CT 06340, United States |
| Abstract: | Dehydrative amide couplings with 2-pyridylamines suffer from variable yields. A mild and high-yielding synthesis of N-(pyridin-2-yl)amides employing 2-aminopyridine-N-oxides is presented as a solution. |
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