Investigation of heterocycles containing nitrogen or sulfur. 47. Reactions of 1,2-dioxo-3a-alkyl-4,7-dichloroxazolidino [3,2-f]pyrido[2,3-b]-1,4-thiazines with saturated cyclic amines. synthesis and structure of derivatives of 1,2-dihydrothiazolo[5,4-b]pyridine |
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Authors: | N P Solov'eva O S Anisimova E M Peresleni K F Turchin Yu N Sheinker L G Levkovskaya L A Serochkina T S Safonova |
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Institution: | (1) Institute of Medicinal Chemistry, VNIKhFI, 119021 Moscow |
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Abstract: | It has been established spectroscopically that 1-N-oxalamides of 2-acyl-5-chloro-1,2-dihydrothiazolo5,4-b] pyridine are formed in the reaction of 4,7-dichloroxazolidino3,2-f]pyrido2,3-b]-1,4-thiazines with morpholine, piperidine and pyrrolidine. The products are a mixture of amide conformers in solution. The reaction intermediate 2-(1-chloro-2-oxobutylthio)-3-pyrrolidinooxamoyl-6-chloropyridine has been isolated and characterized. A proposed reaction scheme is presented.For Communication 46 see 1].Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1125–1132, August, 1993. |
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