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An unexpected inversion of enantioselectivity in the proline catalyzed intramolecular Baylis-Hillman reaction |
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| Authors: | Shang-Hung Chen Cheng-Feng Su |
| Institution: | a Department of Chemistry and Biochemistry, National Chung Cheng University, Chia-Yi 621, Taiwan, ROC b Auspex Pharmaceuticals, Inc. 1261 Liberty Way, Suite C, Vista, CA 92081-8356, USA |
| Abstract: | A highly enantioselective proline catalyzed intramolecular Baylis-Hillman reaction of hept-2-enedial is reported. Addition of imidazole to the mixture results in an unusual inversion of enantioselectivity. |
| Keywords: | Baylis-Hillman Proline Intramolecular Inversion |
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