| L-脯氨酸催化α-酮酰胺与甲基酮的不对称直接Aldol反应 |
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| 引用本文： | 王亚军,沈宗旋,丁娟,张雅文. L-脯氨酸催化α-酮酰胺与甲基酮的不对称直接Aldol反应[J]. 有机化学, 2007, 26(2): 235-239 |
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| 作者姓名： | 王亚军 沈宗旋 丁娟 张雅文 |
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| 作者单位： | 苏州大学化学化工学院,江苏省有机合成重点实验室,苏州,215006 |
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| 摘 要： | 用L-脯氨酸催化α-酮酰胺与甲基酮的不对称直接Aldol反应, 获得了不同光学活性的α-羟基酰胺, 产率在21%～99%之间, 对映选择性最高达到43% ee. 加成产物的结构用元素分析、红外光谱和核磁共振进行了表征.
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| 关 键 词： | 脯氨酸 Aldol反应 α-酮酰胺 α-羟基酰胺 |
| 收稿时间： | 2006-05-08 |
| 修稿时间： | 2006-05-08 |
Asymmetric Aldol Reaction between Methyl Ketones and α-Ketoamides Catalyzed by L-Proline |
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| WANG Ya-Jun,SHEN Zong-Xuan,DING Juan,ZHANG Ya-Wen. Asymmetric Aldol Reaction between Methyl Ketones and α-Ketoamides Catalyzed by L-Proline[J]. Chinese Journal of Organic Chemistry, 2007, 26(2): 235-239 |
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| Authors: | WANG Ya-Jun SHEN Zong-Xuan DING Juan ZHANG Ya-Wen |
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| Affiliation: | Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Suzhou University, Suzhou 215006 |
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| Abstract: | Direct asymmetric aldol addition of methyl ketones to α-ketoamides was achieved using L-proline as a chiral catalyst. Various optically active α-hydroxyamides were obtained in variable yields (21%～99%) with enantioselectivity up to 43% ee. The structures of the adducts were confirmed by elemental analysis, IR, 1H NMR and 13C NMR spectra. |
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| Keywords: | proline aldol addition a-ketoamide a-hydroxyamide |
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