Nickel-catalyzed asymmetric alpha-arylation of ketone enolates |
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| Authors: | Chen Guoshu Kwong Fuk Yee Chan Hoi On Yu Wing-Yiu Chan Albert S C |
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| Institution: | Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis and Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hong Kong. |
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| Abstract: | An atropisomeric dipyridyldiphosphine, P-Phos, can effect highly enantioselective Ni-catalyzed alpha-arylation of ketone enolates with aryl halides to install an all-carbon quaternary stereogenic center in up to 98% ee and excellent yields. |
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