Expedient approach to chiral cyclobutanones: asymmetric synthesis of cyclobut-G |
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| Authors: | Darses Benjamin Greene Andrew E Coote Susannah C Poisson Jean-François |
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| Institution: | Département de Chimie Moléculaire (SERCO) UMR-5250, ICMG FR-2607, CNRS Université Joseph Fourier BP 53, 38041 Grenoble Cedex 9, France. |
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| Abstract: | An efficient one-pot asymmetric synthesis of cyclobutanones from chiral enol ethers is described. The approach is illustrated with alkyl- and functionalized alkyl-substituted enol ethers (nine examples). A new enantioselective synthesis of cyclobut-G (Lobucavir) could thus be achieved. |
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