Lactam and acid amide acetals 68. 1-Cyanomethyl-2-pyrrolidone diethylacetal in the synthesis of 7,8-trimethylenepurine derivatives |
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Authors: | E. N. Dozorova A. V. Kadushkin G. A. Bogdanova N. P. Solov'eva V. G. Granik |
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Affiliation: | (1) Center for the Chemistry of Medicinals, S. Ordzhonikidze All-Union Scientific-Research Institute of Pharmaceutical Chemistry, 119815 Moscow |
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Abstract: | 1-Cyanomethyl-2-cyaniminopyrrolidine was synthesized by the reaction of 1-cyanomethyl-2-pyrrolidone diethylacetal with cyanamide. The product undergoes Thorpe—Ziegler cyclization under the influence of sodium ethoxide to give 2-amino-3-cyano-5,6-dihydro-7H-pyrrolo[1,2-a]imidazole, from which 4-amino derivatives of pyrrolo[2,1-f]purine were synthesized.See [1] for Communication 67.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 754–758, June, 1991. |
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