The tumour-localizing properties of porphyrin derivatives |
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Authors: | S Nakajima H Hayashi Y Omote Y Yamazaki S Hirata T Maeda Y Kubo T Takemura Y Kakiuchi Y Shindo |
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Affiliation: | Department of Surgery, Asahikawa Medical College, Japan. |
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Abstract: | The tumour-localizing abilities of various kinds of porphyrin derivatives in tumour-bearing hamsters were assessed by nitrogen-pulsed laser spectrofluorometry (N2-PLS). On examination of porphine derivatives (from haemoglobin), it was found that the dimer and acetylated and amidated compounds had a high affinity for tumour tissue; the dimer and hydroxylated compound of phorbine derivatives (from chlorophyll) also showed a high affinity. Furthermore, of the metalloporphines (gallium, zinc and indium complexes), those which contained hydrophilic groups showed a high affinity for tumour tissue; of the metallophorbines (gallium, zinc and indium complexes), those which contained hydrophobic groups showed a high affinity. A correlation was found between the side-chain structure of the porphyrins and metalloporphyrins and their affinity for tumour tissue. |
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