Preparation of indoles from alpha-aminonitriles: A short synthesis of FGIN-1-27 |
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| Authors: | Opatz Till Ferenc Dorota |
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| Affiliation: | Institut für Organische Chemie, Universit?t Mainz, Duesbergweg 10-14, D-55128 Mainz, Germany. opatz@uni-mainz.de |
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| Abstract: | Alpha-Aminonitriles derived from 2-aminocinnamic acid esters and amides can be cyclized under basic conditions to furnish substituted indole-3-acetic acid derivatives in quantitative yield. The reaction provides a simple access to a class of biologically active compounds. |
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