几种新的外消旋过渡金属簇合物在纤维素衍生的高效液相色谱手性固定相上的直接拆分

正相条件下,在自制的涂敷型纤维素-三(3,5-二甲基苯基氨基甲酸酯)手性固定相上,首次直接拆分了几种新的外消旋过渡金属簇合物,考察了流动相中极性添加剂对手性拆分的影响.结果发现不仅不同立体结构的醇对手性簇合物的选择性不同,而且手性簇合物四面体骨架的四个顶点上的原子及与之配位的基团,对它们的色谱行为都有重要的影响.

Enantioseparation of Novel Chiral Tetrahedrane-Type Clusters on a Cellulose Tris(3,5-dimethylphenylcarbamate) Chiral Stationary Phase by HPLC

s Direct enantiomeric resolution of five novel chiral tetrahedrane-type clusters has firstly been achieved on cellulose tris(3,5-dimethylphenylcarbamate) chiral stationary phase, using hexane as the mobile phase with various alcohols as modifiers. The influence of the mobile phase composition on the enantioselectivity was discussed, and the effect of structural variation of the solutes on their enantioseparation was also investigated and compared. It was found that both the metal in the tetrahedral core and the ligand coordinated to the atom in tetrahedral core had significant effects on their chromatographic behaviors.