In vivo Monitoring of Organ-Selective Distribution of CdHgTe/SiO2 Nanoparticles in Mouse Model |
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| Authors: | Haiyan Chen Sisi Cui Zhenzhen Tu Yueqing Gu Xuemei Chi |
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| Institution: | (1) Department of Biomedical Engineering, School of Life Science and Technology, China Pharmaceutical University, 24 Tongjia Lane, Gulou District, Nanjing, 210009, China; |
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| Abstract: | CdHgTe/SiO2 nanoparticles were prepared by SiO2 capping on the surface of CdHgTe QDs. The characteristics, such as optical spectra, photostability, size and cell toxicity
were investigated. The dynamic distribution of CdHgTe/SiO2 nanoparticles was in vivo monitored by near infrared fluorescence imaging system. CdHgTe/SiO2 nanoparticles acted as a novel fluorescence probe have a maximum fluorescence emission of 785 nm and high photo-stability.
The hydrodynamic diameter of CdHgTe/SiO2 nanoparticles could be adjusted to 122.3 nm. Compared to CdHgTe QDs, inhibitory effects of CdHgTe/SiO2 nanoparticles on proliferation of HCT116 cells decreased to a certain extent. CdHgTe/SiO2 nanoparticles had their specific dynamic distribution behavior, which provided new perspectives for bio-distribution of nanoparticles. |
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