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Crystal structure of (1rs, 14sr, 17rs, 18rs)-2,20-dioxa-17-methyltricyclo [16,3,0,0] heneicosa-15-ene-3,19,21-trione; a macrocyclic lac |
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| Authors: | David J. Williams |
| Affiliation: | Chemical Crystallography Laboratory, Imperial College, London SW7 2AY, England Department of Chemistry, University of London, King's College, Strand, London WC2R2LS, England Imperial Chemical Industries Ltd., Corporate Laboratory, P.O. Box 11, The Heath, Runcorn, Cheshire WA74OE, England |
| Abstract: | An X-ray study of the major product of the intramolecular Diels-Alder reaction of the diene-anhydride (2) has confirmed it as being the desired cytochalasan analogue (3). In particular the cyclisation has been regioselective, and has taken place via the endo transition state to generate the adduct with the correct relative configurations at the four chiral centres. Details of the conformational geometry of (3) are discussed. |
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