Determination of some banned stimulants in sports by micellar liquid chromatography |
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| Authors: | M Gil-Agustí M E Capella-Peiró A Martinavarro-Domínguez J Esteve-Romero |
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| Institution: | (1) Area de Química Analítica, C.C.E.E.-E.S.T.C.E., Universitat Jaume I, 12081 Castelló, Spain;(2) Servei d'Anàlisis Clíniques, Hospital Verge dels Llíris, 03804 Alcoi, Alacant, Spain |
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| Abstract: | Summary A procedure has been developed for the determination, in <12 min, of several stimulants (amphetamine, ephedrine, methoxyphenamine,
phenylephrine and phenylpropanolamine) in spiked urine samples after direct injection, using a hybrid micellar mobile phase
of 0.15 M sodium dodecyl sulfate and 3% pentanol at pH 7, on a C18 column with UV detection. Recoveries were 94–102% and limits of detection 4.5 ng·mL−1 for methoxyphenamine and 0.39 μg·mL−1 for amphetamine, similar to those obtained for aqueous solutions. Linearity reached 0.99 and intermediate precision was <8.4
and 5.3, for the two different concentrations tested. |
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| Keywords: | Column liquid chromatography Micellar liquid chromatography Direct urine injection Banned sports stimulants |
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