Highly enantioselective CH oxidation of vic-Diols with Shi's oxazolidinone dioxiranes |
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Authors: | Jakka Kavitha Zhao Cong-Gui |
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Affiliation: | Department of Chemistry, University of Texas at San Antonio, 78249-0698, USA. |
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Abstract: | [reaction: see text] Through an analogical study of the transition states of CH oxidation and asymmetric epoxidation of terminal alkenes, the first dioxirane-mediated catalytic highly enantioselective CH oxidation method was realized with Shi's oxazolidinone ketone derivatives. Very good enantioselectivity (up to 92% ee) may be obtained for both asymmetrization of meso vic-diols and kinetic resolution of racemic vic-diols. |
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