Reaction of 5-hydroxy-3,3,5-trimethylisoxazolidine with acrylic acid esters

The reaction of 5-hydroxy-3,3,5-trimethylisoxazolidine with methyl, ethyl, and tert-butyl acrylates, proceeds as Michael addition, and produces previously, unknown 5-hydroxy-3,3,5-trimethylisoxazolidine-2-propionic acid esters. The structures of the obtained products are proved by¹H and¹³C NMR spectroscopy and by their subsequent transformation into 5-hydroxy-3,3,5-trimethylisoxazolidine-2-propionic acid.Institute of High-Molecular Compounds, Russian Academy of Sciences, St. Petersburg 199004, Russia; St. Petersburg State University, St. Petersburg 198904, Russia Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 945–947, July, 1999.