Studies of the elimination of 4-aryl-3-methyl-4-piperidinols—I The conformation of epimeric 1-alkyl (and aralkyl)-4-aryl-5-methyl-1,2,5-6-tetrahydropyridine hydrochlorides |
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Authors: | A. F. Casy A. H. Beckett M. A. Iorio H. Z. Youssef |
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Affiliation: | School of Pharmacy, Chelsea College of Science and Technology, London U.K. |
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Abstract: | A detailed study of the products of elimination of some 4-aryl-3-methyl-4-piperidinols has been made and the PMR spectra of derived 1-alkyl (and aralkyl)-4-aryl-5-methyl-1,2,5,6-tetrahydropyridines and the corresponding hydrochloric salts reported and discussed. The 5-methyltetrahydropyridine hydrochlorides are shown to exist in epimeric forms in deuterochloroform and their PMR spectra have been interperted in terms of probable conformations. |
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