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Aerosol-Assisted Plasma Deposition of Hydrophobic Polycations Makes Surfaces Highly Antimicrobial |
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| Authors: | Harris Liu Yoojeong Kim Kerrianne Mello John Lovaasen Apoorva Shah Norman Rice Jacqueline H. Yim Daphne Pappas Alexander M. Klibanov |
| Affiliation: | 1. Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA 3. Triton Systems, Inc., 200 Turnpike Road, Chelmsford, MA, 01824, USA 5. Triton Systems, Inc., 1854 Research Circle North, Suite 215, Fargo, ND, 58102, USA 4. US Army Research Laboratory, Multifunctional Materials Branch, Weapons & Materials Research Directorate, Aberdeen Proving Ground, Aberdeen, MD, 21005-5069, USA 2. Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA |
| Abstract: | The currently used multistep chemical synthesis for making surfaces antimicrobial by attaching to them hydrophobic polycations is replaced herein by an aerosol-assisted plasma deposition procedure. To this end, N,N-hexyl,methyl-PEI (HMPEI) is directly plasma-coated onto a glass surface. The resultant immobilized HMPEI coating has been thoroughly characterized and shown to be robust, bactericidal against Escherichia coli, and virucidal against human influenza virus. |
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