Multiphase heterogeneous catalytic enantioselective hydrogenation of acetophenone over cinchona-modified Pt/C |
| |
Authors: | Alvise Perosa Pietro Tundo and Maurizio Selva |
| |
Institution: | Dipartimento di Scienze Ambientali, Università Ca’ Foscari, Dorsoduro 2137, 30123, Venezia, Italy |
| |
Abstract: | The multiphase heterogeneous enantioselective hydrogenation of acetophenone in the presence of cinchona-modified Pt/C was investigated. The system demonstrated the feasibility of this reaction on non-activated ketones. The reaction proceeded selectively, at room temperature and atmospheric pressure, towards the formation of 1-phenylethanol, with up to 20% ee (enantiomeric excess) of either enantiomer depending on the modifier used. A mode of action of the modifier is proposed to account for the mechanism. A comparison with other systems indicates that the investigated system likely acts by a different mechanism, and that it is quite specific for acetophenone. |
| |
Keywords: | Hydrogenation Acetophenone Cinchona Enantioselective Multiphase |
本文献已被 ScienceDirect 等数据库收录! |
|