Iridium complex bearing a chiral hydroxy-amide functionalized N-heterocyclic carbene: a catalyst precursor for asymmetric transfer hydrogenation |
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| Authors: | Hiroyuki ChiyojimaSatoshi Sakaguchi |
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| Institution: | Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Suita, Osaka 564-8680, Japan |
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| Abstract: | A new monodentate iridium(III) complex bearing a readily accessible and tunable chiral hydroxy-amide functionalized N-heterocyclic carbene ligand, Cp∗Ir(NHC)Cl2, has been synthesized and characterized by crystallographic methods. The monodentate Cp∗Ir(NHC)Cl2 complex was found to act as a catalyst precursor for the stereoselective transfer hydrogenation of acetophenone in the presence of KOH even at room temperature. Moderate enantioselectivity was observed in the initial screening of the chiral ligands. |
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| Keywords: | N-Heterocyclic carbene Iridium complex Asymmetric transfer hydrogenation Catalyst precursor Highly tunable NHC ligand |
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