| 基于低温超导量子干涉器件的脑 听觉激励磁场探测 |
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| 引用本文： | 张树林,刘扬波,曾佳,王永良,孔祥燕,谢晓明.基于低温超导量子干涉器件的脑 听觉激励磁场探测[J].物理学报,2012,61(2):20701-020701. |
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| 作者姓名： | 张树林 刘扬波 曾佳 王永良 孔祥燕 谢晓明 |
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| 作者单位： | 信息功能材料国家重点实验室, 中国科学院上海微系统与信息技术研究所, 上海 200050;中国科学院研究生院, 北京 100049;信息功能材料国家重点实验室, 中国科学院上海微系统与信息技术研究所, 上海 200050;中国科学院研究生院, 北京 100049;信息功能材料国家重点实验室, 中国科学院上海微系统与信息技术研究所, 上海 200050;中国科学院研究生院, 北京 100049;信息功能材料国家重点实验室, 中国科学院上海微系统与信息技术研究所, 上海 200050;信息功能材料国家重点实验室, 中国科学院上海微系统与信息技术研究所, 上海 200050;信息功能材料国家重点实验室, 中国科学院上海微系统与信息技术研究所, 上海 200050 |
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| 基金项目： | 国家高技术研究发展计划(批准号:2008AA02Z308)和上海市科学技 术委员会（批准号:08JC1421800)资助的课题. |
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| 摘 要： | 本文利用磁屏蔽室和二阶轴向梯度计抑制环境磁场噪声, 建立了单通道脑磁探测系统, 并对不用声音频率下脑听觉激励磁场N100m响应进行了初步探测.结果显示, 1000 Hz音频和100 ms持续声音激励下, N100m峰值的典型强度约为0.4 pT.在低的声音频率激励下, N100m峰出现延时, 100 Hz 和1000 Hz之间的延时差别达到25 ms.相比于1 kHz特定频率的声音激励, 1—4 kHz 随机变频下的N100m峰幅度增强, 出现了数毫秒的延时.本研究为下一步利用软件梯度计进行多通道脑磁系统和听觉机理研究奠定了一定的基础.
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| 关 键 词： | 超导量子干涉器件 脑磁 梯度计 听觉激励 |
| 收稿时间： | 2012-02-27 |
| 修稿时间： | 5/6/2011 12:00:00 AM |
Detection of brain auditory evoked magnetic field based on low-Tc superconducting quantum interface device |
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| Zhang Shu-Lin,Liu Yang-Bo,Zeng Ji,Wang Yong-Liang,Kong Xiang-Yan and Xie Xiao-Ming.Detection of brain auditory evoked magnetic field based on low-Tc superconducting quantum interface device[J].Acta Physica Sinica,2012,61(2):20701-020701. |
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| Authors: | Zhang Shu-Lin Liu Yang-Bo Zeng Ji Wang Yong-Liang Kong Xiang-Yan and Xie Xiao-Ming |
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| Institution: | State Key Laboratory of Functional Materials for Informatics, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China; Graduate University of Chinese Academy of Sciences, Chinese Academy of Science;State Key Laboratory of Functional Materials for Informatics, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China; Graduate University of Chinese Academy of Sciences, Chinese Academy of Science;State Key Laboratory of Functional Materials for Informatics, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China; Graduate University of Chinese Academy of Sciences, Chinese Academy of Science;State Key Laboratory of Functional Materials for Informatics, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China;State Key Laboratory of Functional Materials for Informatics, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China;State Key Laboratory of Functional Materials for Informatics, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China |
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| Abstract: | Superconducting quantum interface devices (SQUID) is widely used in human brain signal detection. As one of the applications of magnetoencephalography (MEG) system, the detection of the auditory evoked response is useful for the development of MEG system and the research into auditory mechanism of human brain. Generally, the auditory evoked response includes three peaks which are P50m, N100m and P200m. We develop a single-channel MEG system in a magnetically shielded room based on the superconducting quantum interface device (SQUID) and second-order axial gradiometer. The responses of the main peak N100m under different tone frequencies are preliminarily studied by using our system. The typical evoked response of N100m to 1 kHz pure tone and 100 ms duration is measured to be 0.4 pT. Under the tone stimulus at low frequency, the delay of the peak N100m to the tone onset is 125 ms at 100 Hz, which is longer than the typical value of 100 ms. In comparison with the response to 1 kHz pure tone stimulus, the amplitude of the evoked response in a random frequency range from 1 kHz to 4 kHz is stronger and the delay is several milliseconds. This work lays the foundation of the studies of the auditory mechanism and multichannel MEG system by using software gradiometers. |
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| Keywords: | superconducting quantum interface device (SQUID) magnetoencephalography (MEG) gradiometer auditory stimulus |
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