Synthesis of novel,azasugar-modified anthraquinone derivatives and their cytotoxicity |
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| Authors: | Ping-Zhu Zhang, Hai-Long Yang, Cui-Cui Li, Zhi-Chao Xia, Xiao-Man Wang, Hua Wei, Rui-Xue Rong, Zhi-Ran Cao, Ke-Rang Wang, Hua Chen, Xiao-Liu Li |
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| Affiliation: | a Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China;b Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding 071002, China;c Department of Immunology, School of Basic Medical Science, Hebei University, Baoding 071002, China |
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| Abstract: | A series of novel, azasugar-modified 2-monosubstituted, 2,6- and 2,7-bissubstituted anthraquinone derivatives have been synthesized by the nucleophilic substitution of N-alkylamino azasugar with mono-, bis(2-chloroacetamido)anthraquinones. Their cytotoxic activities against HeLa and MCF-7 cells were preliminarily evaluated and compound 9a with mono-azasugar pendant at 2-position showed similar activity to the control drug(Cisplatin). |
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| Keywords: | Anthraquinone Azasugar Cytotoxic activity |
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