Synthesis,insecticidal activity and molecular docking study of clothianidin analogues with hydrazide group |
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| Authors: | Shao-Hua Liu, Wei Peng, Yan-Yan Qu, Dan Xu, Hong-Yue Li, Dun-Lun Song, Hong-Xia Duan, Xin-Ling Yang |
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| Affiliation: | a Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China;b Department of Entomology, College of Agriculture and Biotechnology, China Agricultural University, Beijing 100193, China |
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| Abstract: | A series of novel neonicotinoid analogues were designed and synthesized by introducing a hydrazide group into clothianidin. Their structures were confirmed by IR,1H NMR, and HRMS(ESI). Preliminary bioassay showed that some compounds, 5b and 5g, exhibited good activity against soybean aphids(Aphis glycines) at 100 mg L 1. In addition, molecular docking with receptor was carried out to explain their different activity from clothianidin. |
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| Keywords: | Clothianidin analogues Hydrazide group Insecticidal activity Molecular docking |
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