N-Fluorinated phenyl-N'-pyrimidyl urea derivatives: Synthesis,biological evaluation and 3D-QSAR study |
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作者姓名: | Xia-Li Yue Hu Li Shuang-Shuang Liu Qing-Ye Zhang Jing-Jing Yao Fei-Yan Wang |
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作者单位: | College of Science, Huazhong Agricultural University, Wuhan 430070, China |
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基金项目: | This work was supported by the National Natural Science Foundation of China (No. 30900935), and the Fundamental Research Funds for the Central Universities (Nos. 2011PY086, 2011PY039). |
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摘 要: | With the increase of herbicide-resistant weeds, novel, more selective and even more potent herbicides to control weeds are needed. In this paper, a series of N-fluorinated phenyl-N'-pyrimidyl urea derivatives were synthesized and screened for their herbicidal activities against Amaranthus retroflexus (AR) and Setaria viridis ( SV). Compound 2S (N-(3-trifluoromethylphenyl)-N'-(2-amino-4-chloro-6-methylpyr- imidyl) urea) exhibited marked herbicidal activity against SV(IC50 =11.67 mg/L) and is more potent than bensulfuron (IC50= 27.45 mg/L), a commercially available herbicide. A statistically significant CoMFA model with high prediction abilities (q2 = 0.869, r2 = 0.989) was obtained.
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关 键 词: | 3D-QSAR 脲衍生物 甲基苯基 生物学评价 氟化 合成 嘧啶 抗除草剂 |
收稿时间: | 2013-12-31 |
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