| ＂Amano＂ lipase DF-catalyzed efficient synthesis of 2,2＇-arylmethylene dicyclohexane-1,3-dione derivatives in anhydrous media |
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| 作者姓名： | Ling Jiang, BoWang, Rong-Rong Li, Sa Shen, Hong-Wei Yu, Li-Dan Ye |
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| 作者单位： | a Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310007, China;b College of Materials and Chemical Engineering, Hainan University, Haikou 570228, China;c School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China |
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| 基金项目： | This work was financially supported by the Outstanding Young Scholar Grant of Zhejiang University （No. R4110092）, the National Natural Science Foundation of China （No. 21176215/21176102） and the Program for Zhejiang leading team afS＆T Innovation （No. 2011R50007）. We thank all of the constructive comments and suggestions from the editors and reviewers. |
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| 摘 要： | A simple and efficient method was developed for the synthesis of 2.2＇-arylmethylene dicyclohexane-1,3- dione derivatives via the Knoevenagel-Michael cascade reactions of aromatic aldehydes and 1,3-cyclic diketones catalyzed by ＂Amano＂ lipase DF, which expands the application field of enzyme catalytic promiscuity. This protocol provides several advantages over the traditional chemical synthesis, such as simple work-up procedure, high yields Cup to 94%） and environmental friendliness.
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| 关 键 词： | 芳亚甲基 高效合成 酮衍生物 酶催化 Knoevenagel反应 脂肪酶 环己烷 水介质 |
| 收稿时间： | 2013-12-30 |
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