Synthesis and cytotoxicity evaluation of a novel justicidin G analogue and its phosphate ester |
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| Authors: | Sheng-Peng Wang, Yuan-Feng Tong, Dong-Mei Wang, Nan Wang, Zheng Yan, Ping Huang, Song Wu |
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| Affiliation: | a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China;b Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China |
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| Abstract: | The novel justicidin G analogue 13 and its phosphate ester 15 were synthesized as potential anticancer agents in several steps starting from commercially available methyl gallate and veratraldehyde. The cytotoxicity of the intermediates was tested against HCT-8, BEL-7402, KETR3, HELA, BGC-823, KB and MCF-7 cell lines by the MTT test, and compound 15 exhibited significant cytotoxicity in HELA and KB cell lines. |
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| Keywords: | Justicidin G Analogue Phosphate ester Antitumor activity Synthesis |
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