Infrared spectra of proteins and lipids in human breast malignant tissues |
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| Authors: | I V Skornyakov G B Tolstorozhev and V A Butra |
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| Institution: | (1) B. I. Stepanov Institute of Physics, National Academy of Sciences of Belarus, 68 Nezavisimosti Ave., Minsk, 220072, Belarus;(2) Department of Oncological Morphology of the City Clinical Pathologic Anatomy Bureau, Minsk, Belarus |
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| Abstract: | IR spectroscopy methods have been adopted for investigating resected tissues of mammary glands. IR spectra of surgical material
are compared with histological data. Spectra of proteins and lipids in malignant tumors are shown to be different from those
in benign tumors and in tissues outside the pathologically impacted volume. Differences in the protein spectra are due to
changes in the supramolecular structure because of the cleavage of intramolecular C=O⋅⋅⋅H–N H-bonds. Spectral signatures of
malignant pathologies are identified.
Translated from Zhurnal Prikladnoi Spektroskopii, Vol. 76, No. 2, pp. 261–266, March–April, 2009. |
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| Keywords: | malignant tumor IR spectrum protein lipid structure H-bond |
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