| ISOLATION AND STRUCTURE OF RANAMARGARIN,A NEW TACHYKININ FROM THE SKIN OF CHINESE FROG Rana margaratae |
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| 引用本文： | 唐易全,田盛海,吴时祥,华家柽,吴贯夫,赵尔宓,陆一安,朱应麒,邹冈. ISOLATION AND STRUCTURE OF RANAMARGARIN,A NEW TACHYKININ FROM THE SKIN OF CHINESE FROG Rana margaratae[J]. 中国科学B辑(英文版), 1989, 0(5) |
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| 作者姓名： | 唐易全 田盛海 吴时祥 华家柽 吴贯夫 赵尔宓 陆一安 朱应麒 邹冈 |
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| 作者单位： | Shanghai Institute of Materia Medica，Academia Sinica，Shanghai Institute of Materia Medica，Academia Sinica，Shanghai Institute of Materia Medica，Academia Sinica，Shanghai Institute of Materia Medica，Academia Sinica，Chengdu Institute of Biology，Academia Sinica，Chengdu Institute of Biology，Academia Sinica，Shanghai Centre of Biotechnology，Academia Sinica，Shanghai Centre of Biotechnology，Academia Sinica，Shanghai Institute of Materia Medica，Academia Sinica |
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| 摘 要： | A new tetradecapeptide, ranamargarin, has been isolated by Sep-Pak C_(18) and HPLC from methanol extracts of the skin of the Chinese frogRana margaratae. The sequence of the peptide is: Asp-Asp-Ala-Ser-Asp-Arg-Ala-Lys-Lys-Phe-Tyr-Gly-Leu-Met-NH_2. This structure has been confirmed by synthesis. The peptide is the largest among the amphibian tachykinins and its N-terminal amino acids are quite different from those of the other tachykinins. The formation of the sulfoxide and peak-splitting of ranamargarin during purification procedures are briefly discussed.
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ISOLATION AND STRUCTURE OF RANAMARGARIN,A NEW TACHYKININ FROM THE SKIN OF CHINESE FROG Rana margaratae |
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| TANG YI-QUAN TIAN SHENG-HAI WU SHI-XIANG HUA JIA-CHENG WU GUAN-FU ZHAO ER-MI LU YX-AN ZHU YING-QI AND ZOU GANG. ISOLATION AND STRUCTURE OF RANAMARGARIN,A NEW TACHYKININ FROM THE SKIN OF CHINESE FROG Rana margaratae[J]. Science in China(Chemistry), 1989, 0(5) |
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| Authors: | TANG YI-QUAN TIAN SHENG-HAI WU SHI-XIANG HUA JIA-CHENG WU GUAN-FU ZHAO ER-MI LU YX-AN ZHU YING-QI AND ZOU GANG |
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| Abstract: | A new tetradecapeptide, ranamargarin, has been isolated by Sep-Pak C_(18) and HPLC from methanol extracts of the skin of the Chinese frogRana margaratae. The sequence of the peptide is: Asp-Asp-Ala-Ser-Asp-Arg-Ala-Lys-Lys-Phe-Tyr-Gly-Leu-Met-NH_2. This structure has been confirmed by synthesis. The peptide is the largest among the amphibian tachykinins and its N-terminal amino acids are quite different from those of the other tachykinins. The formation of the sulfoxide and peak-splitting of ranamargarin during purification procedures are briefly discussed. |
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| Keywords: | ranamargarin Rana margaratae amphibian skin HPLC sequence analysis. |
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