Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
Abstract:
Copolymers mPEG-PCL were prepared and grafted onto polyethylenimine(PEI) to synthesize copolymers mPEG-PCL-g-PEI with low cytotoxicity.The mPEG-PCL-g-PEI could condense siRNA to form nanoparticles with positive zeta potential.These nanoparticles could delivery siRNA into cells to effectively inhibit the expression of target gene,which suggested that mPEG-PCL-g -PEI could serve as a highly efficient vector for siRNA delivery.