Isolation, structure determination, and synthesis of galaxamide, a rare cytotoxic cyclic pentapeptide from a marine algae Galaxaura filamentosa |
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| Authors: | Xu Wen-Jie Liao Xiao-Jian Xu Shi-Hai Diao Jian-Zhong Du Bin Zhou Xu-Long Pan Shan-Shan |
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| Institution: | Institute of Hydrobiology, Jinan University, Huangpu Road West 601, Guangzhou, Guangdong 510632, People's Republic of China. |
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| Abstract: | Galaxamide (1), a rare cyclic pentapeptide, was isolated from the marine algae Galaxaura filamentosa. A preliminary bioassay of Galaxamide showed remarkable in vitro antiproliferative activities against GRC-1 and HepG2 cell lines. The first total synthesis of the cyclic peptide was achieved for further biological evaluation. |
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