Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide |
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| Authors: | Paterson Ian Naylor Guy J Wright Amy E |
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| Institution: | University Chemical Laboratory, Lensfield Road, Cambridge, UKCB2 1EW. ip100@cam.ac.uk |
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| Abstract: | A potent dictyostatin-discodermolide hybrid was designed and synthesised; it showed enhanced cell growth inhibitory activity relative to discodermolide in four human cancer cell lines including the Taxol-resistant NCI/ADR-Res cell line. |
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